This relationship between FGF21, adiponectin, and insulin might explain the changes in their levels observed in FMT-colitis group mice in this study, which were declines in FGF21 and adiponectin (Figs 2F, 2G, 3O and 3P) accompanied by elevated plasma insulin level (Fig 2H) and decreased insulin signaling in adipose tissue (Fig 2I). This evidence concerns the gene ADIPOQ and colitis.