A recent study examining chimeric oligonucleotides, comprised of a 2’-O-methyl-modified ASO against the SARS-CoV-2 S transcript and a 5’-phosphorylated 2’-5’ poly(A)4 that guides RNase L into cleave the viral ssRNA, found that the chimeras inhibited infection in SARS-CoV-2 pseudovirus models [33]. The gene discussed is RNASEL; the disease is infection.