All of the mouse studies of mosquito saliva effects reported previously have used mice that differ from human immune systems: AG129 (which lack type I and type II IFN receptors), BALB/c mice (which are predisposed to TH2 immune responses), C57BL/6 mice (which are predisposed to TH1 immune responses), C3H/HeJ (which have a B cell deficiency), and C3H/PRI-Flvr (which are resistant to flavivirus infection) [36,37,47,48,51–54]. The gene discussed is SGCG; the disease is B cell deficiency.