As JAKs are activated by cytokine receptors and several studies proposed autocrine IL-6 signaling in tumor cell lines (Kawashima et al., 2001; Yeh et al., 2006; Gao et al., 2007; Hartman et al., 2011; Rodriguez-Barrueco et al., 2015), we envisaged an autocrine activity of IL-6 produced by BCR-stimulated neonatal CD19+CD43- B cells. This evidence concerns the gene SPN and neoplasm.