The hallmark of FHA diagnosis is hypogonadotropic hypogonadism related to the suppression of the pulsatile release of hypothalamic gonadotropin-releasing hormone (GnRH) which in turn impairs the pulsatile release of luteinizing hormone (LH) with reduced secretion of 17ß-estradiol (E2) by the ovary [4]. The gene discussed is GNRH1; the disease is hypoalphalipoproteinemia, primary, 1.