Genes responsible for the carcinogenesis of CRC are already known partially, including the following: microsatellite instability (MSI) as a manifestation of mismatch repair (MMR) gene (MLH1, MSH2, MSH6, PMS1, and PMS2) germline deficiency,9, 10 biallelic MUTYH mutations leading younger‐age onset of CRC,11 and germline mutation of genes coding for deoxyribonucleic acid (DNA) polymerase (POLE and POLD).12 This evidence concerns the gene POLE and colorectal carcinoma.