Genes responsible for the carcinogenesis of CRC are already known partially, including the following: microsatellite instability (MSI) as a manifestation of mismatch repair (MMR) gene (MLH1, MSH2, MSH6, PMS1, and PMS2) germline deficiency,9, 10 biallelic MUTYH mutations leading younger‐age onset of CRC,11 and germline mutation of genes coding for deoxyribonucleic acid (DNA) polymerase (POLE and POLD).12 The gene discussed is POLD1; the disease is colorectal carcinoma.