TNF and heart disorder: Interestingly, inflammatory markers monocyte chemoattractant protein‐1 (MCP‐1) and tumor necrosis factor‐α (TNF‐α), associated with age‐related diseases including cardiac disease, (Bellisarii et al., 2001; Niu & Kolattukudy, 2009) were also elevated in the serum of Ckmm‐Cre+/−;Ercc1/fl mice at 6 months compared to age‐matched controls and no change in 2–3 months of age mice (Figure 2j,k and Figure S11f,g).