TP53 and dilated cardiomyopathy: Similarly, dilated cardiomyopathy frequently occurs during accelerated aging, driven by, for example, viral infection, cancer chemotherapy, and diabetes (Bloom et al., 2016; Prandi et al., 2022; Tschöpe et al., 2021) At the cellular level, cardiac myocytes isolated from mice with myocyte‐specific or systemic depletion of Ercc1 expression were hypersensitive to genotoxic stress and prone to apoptosis via a p53‐dependent mechanism.