In addition, FLNA is a causal gene of OPDSD, and missense point mutations cause a large range of clinical symptoms in females, such as palatoschisis, palpebral fissures, micrognathia, cardiovascular abnormity, skeletal dysplasia and other organ deformities, through gain‐of‐function effects (Iwamoto et al., 2018). This evidence concerns the gene FLNA and skeletal dysplasia.