The mRNA expression of all four genes was higher in PCa cell lines compared with non-malignant prostate cells, with the highest expression of METTL3, METTL14, WTAP and CBLL1 observed in the androgen-dependent LNCaP and in castrate-resistant 22Rv1 cells which also express AR variants. The gene discussed is METTL3; the disease is posterior cortical atrophy.