CD40LG and Huntington disease: A meta-analysis of the accuracy of diagnostic tests for HD (68) that included 78 studies concluded that, although test accuracy appears reasonable, the studies suffered from heterogeneity and poor methodological quality, most of them evaluating the detection of IgM antibodies against phenolic glycolipid-I by ELISA with 63.8% sensitivity (95% CI: 55.0–71.8) and 91.0% specificity (95% CI: 86.9–93.9) in 39 of the studies while the sensitivity of qPCR (five studies) was 78.5% (95% CI: 61.9–89.2) and specificity was 89.3% (95% CI 61.4–97.8).