Mooney et al. reported that an alginate gel loaded with a Dox-iRGD conjugate, granulocyte-macrophage colony stimulating factor (GM-CSF) and CpG, could enhance ICD of tumor cells, increase CD8+ T cells, and repolarize tumor-associated macrophages (TAMs) towards M1 phenotype, leading to significantly inhibited TNBC primary tumor and metastases [22]. This evidence concerns the gene CD8A and neoplasm.