HDAC4 and chondrosarcoma: At the same time, HDAC4 partially blocks the effect of IL-1 on the expression of catabolic genes such as iNOS, COX-2, ADAMTS-4 and -5. In contrast, Lu and his colleagues have shown that HDAC4 invalidation on a human chondrosarcoma cell line SW1353 suppresses the expression of MMP-1, -3, -13, and ADAMTS-4 but also the expression of several anabolic genes such as ACAN (Lu et al., 2014).