Intriguingly, cardiac hypertrophy induced by transverse aortic constriction (TAC) in 2-month-old mice for 1 week resulted in a similar degree of heart growth and increase in ventricular wall thickness between Rpl3l−/− and wild type mice; however, wild type mice subjected to TAC exhibited re-expression of the RPL3 protein and loss of RPL3L, similar to the transgenic models of hypertrophy (Figures 4D–F). This evidence concerns the gene RPL3 and cardiac hypertrophy.