PDZK1IP1 and systemic sclerosis: NT-proANP plasma level was significantly increased in SSc patients with the TAPSE/sPAP ratio < 0.7 mm/mmHg compared with patients with the TAPSE/sPAP ratio ≥ 0.7 mm/mmHg [2735 (1815–4023) vs. 1511 (1221–1821) fmol/ml; p < 0.001] (Figure 3B).