In the above studies, among ccRCC tumor tissues the piR-32051, piR-39894, piR-43607, piR-30924, and piR-38756 were all up-regulated where this up-regulation was closely related to cancer metastasis and low specific survival rate which can be used as prognostic markers, while piR-31115 and piR-57125 can regulate ccRCC progression making them potential therapeutic targets for ccRCC. The gene discussed is PIR; the disease is cancer.