The previous study showed that the expression of MUC5B was significantly elevated in pancreatic tissue of patients with T2DM compared to those without T2DM (38), therefore, we speculated that MUC5B rs2943512 (A>C) might cause the over-expression of MUC5B in lung tissue of T2DM patients. This evidence concerns the gene MUC5B and type 2 diabetes mellitus.