MUC5B SNP rs2943512 (A > C) or the up-regulated MUC5B in bronchial epithelial cells may be an important factor in promoting ILD in T2DM patients, making MUC5B a potential biological marker for the development of ILD in diabetic patients, and laying a foundation for future exploration about the pathogenesis of T2DM complicated with ILD. Here, MUC5B is linked to interstitial lung disease.