The evidence reported around the positive effect of MBS and weight loss and decrease in MetS, is associated with the remission of insulin resistance, accompanied by the restrictive component; in obesity, before the high load of glucose concentrations, the beta‐pancreatic cells have to respond with an abnormal hypersecretion of insulin, and because this constant stimulation, the failure of the pancreatic beta cells is generated, decreasing the production of insulin. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.