Liver metastasis (hazard ratio [HR] 2.10, 95% CI: 1.33-3.31), bone metastasis (HR 1.56, 95% CI: 1.05-2.31), brain metastasis (HR 1.98, 95% CI: 1.14-3.45), number of metastases (HR 2.02, 95% CI: 1.24-3.28), WBC >10,000/mm3 (HR 2.31, 95% CI: 1.54-3.46), dNLR>3 (HR 1.68, 95% CI: 1.10-2.55), serum albumin <3.5 g/dL (HR 1.70, 95% CI: 1.08-2.67), LDH >ULN (HR 2.50, 95% CI: 1.66-3.76), CRP 31.0 mg/dL (HR 2.17, 95% CI: 1.40-3.37), and ECOG PS 32 (HR 2.60, 95% CI: 1.72-3.95) were associated with worse OS outcomes. ﻿Patients with unknown PD-L1 levels (HR 0.57, 95% CI: 0.36-0.91) showed better OS. The gene discussed is CRP; the disease is bone metastasis.