Jianpi Yangzheng decoction, an effective recipe for advanced gastric cancer, decreases the abundance of serum exosomal PKM2, reduces the delivery of exosomal PKM2 from tumor cells to macrophages, and alleviates exosomal PKM2-induced differentiation of M2-TAMs (Wu W et al., 2022). This evidence concerns the gene PKM and gastric cancer.