The exosomal ENO1 promotes growth and metastasis of HCC with low metastatic potential by regulating integrin α6β4 and the activation of FAK/Src-p38MAPK pathway, suggesting that ENO1 can be transferred to other HCC cells via exosome-mediated crosstalk and further promotes HCC growth and metastasis (Jiang et al., 2020). Here, PTK2 is linked to hepatocellular carcinoma.