Fang et al. (Fang et al., 2018) showed that high-metastatic HCC cells-derived exosomal miR-1247-3p induced lung fibroblast activation to foster lung metastasis of liver cancer through targeting B4GALT3 and thereby activating β1-integrin-NFκB signaling in fibroblasts. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.