Jianpi Yangzheng decoction, an effective recipe for advanced gastric cancer, decreases the abundance of serum exosomal PKM2, reduces the delivery of exosomal PKM2 from tumor cells to macrophages, and alleviates exosomal PKM2-induced differentiation of M2-TAMs (Wu W et al., 2022). The gene discussed is PKM; the disease is neoplasm.