Mechanistically, suppression of MET blocked GSK3β phosphorylation and promoted the interaction between TRAF6 and GSK3β, leading to inactivation of GSK3β because of TRAF6-induced GSK3β K63 ubiquitination, which facilitated the PD-L1 expression in HCC cells (87). Here, GSK3B is linked to hepatocellular carcinoma.