Since CST1 was the only key gene that was up-regulated in the nasal epithelium and bronchial epithelium of both AR and asthma patients, and the correlation heatmap showed that CST1 was the most correlated gene with the other three key genes, we speculated CST1 might be the primary driver among key genes and was more likely to be an effective target for drug therapy. This evidence concerns the gene CST1 and asthma.