Increased ADAM17 activity was observed after myocardial infarction (MI) (Akatsu et al., 2003; Ghaderian et al., 2011; Guan et al., 2021), whereas ADAM17 inhibition decreased the amount of fibrosis after MI in mice (Guan et al., 2021). The gene discussed is ADAM17; the disease is myocardial infarction.