ADAM17 and familial dilated cardiomyopathy: Apart from that, increased ADAM17 activity was also found in patients with acute myocarditis, and hypertrophic cardiomyopathy or dilated cardiomyopathy (DCM), as well as in mice with diabetic cardiomyopathy (Satoh et al., 1999; Satoh et al., 2000; Fedak et al., 2006; Xue et al., 2022).