IFT172 and ciliopathy: In terms of mechanism exploration, although there are no reports of abnormal direct interactions between IFT172 and receptors enriched on primary cilia leading to ciliopathies, in the case of absence of IFT172, these receptors and their coupled downstream signaling pathways are often affected, as cilia are the physical basis for the functions of these receptors, and the absence of IFT172 affects cilia formation (Pala et al., 2017).