Furthermore, this study demonstrated that the high-fiber-diet-associated metabolite acetamidobenzoic acid can bind to the SPEG (6CY6) protein in the hippocampus and affect autophagic homeostasis in the hippocampus, thus improving the diabetic and neurodegenerative disease states of individuals with obesity. This evidence concerns the gene SPEG and obesity due to melanocortin 4 receptor deficiency.