TNF and Insulin resistance: Therefore, based on the hypoglycemic activity of two iridoids (patrinoside and patrinoside A) found in previous studies [17], this experiment established RAW264.7 inflammation model to preliminarily screen the anti-inflammatory activity of patrinoside and patrinoside A. And then TNF-α induced 3 T3-L1 cell create insulin resistance inflammatory model to further determine the mechanism on improving IR of patrinode and patrinoside A related to anti- inflammation.