Most serum inflammation factors (MCP-1, IL-1β, IL-6, IL-8, TNF-α, and TLR4) were expressed higher in patients after 3 months of doxorubicin therapy with HF compared with the levels in the Dox-baseline groups (MCP-1, P = 0.014; IL-1β, P = 0.017; IL-6, P = 0.025; IL-8, P = 0.009; TNF-α, P = 0.021; and TLR4, P = 0.024). The gene discussed is IL1B; the disease is hydrops fetalis.