Serum antioxidant biomarkers were lower in patients diagnosed with HF after 3 months of doxorubicin therapy compared with those in the Dox-baseline groups (GSH, P = 0.017; GR, P = 0.022; GPx, P = 0.013; and SOD, P = 0.018). The gene discussed is SOD1; the disease is hydrops fetalis.