METTL1 and malignant colon neoplasm: Another group reported that METTL1 inhibited colon cancer by increasing let-7e miRNA and decreasing its target gene HMGA2. Moreover, overexpression of METTL1 enhanced the cytotoxic effects of cisplatin on colon cancer cells by triggering the miR-149-3p/S100A4/p53 axis [28].