WDR4 and central nervous system cancer: We also carried out stratified analysis for WDR4 gene SNPs (Table 3) and found that rs15736 showed significant protective effects in children aged 60 months or older (adjusted OR = 0.58, 95%CI = 0.34 − 0.995, P = 0.048), girls (adjusted OR = 0.55, 95%CI = 0.31 − 0.98, P = 0.042), the subgroup with astrocytic tumors (adjusted OR = 0.54, 95%CI = 0.34 − 0.87, P = 0.011), and those with grade I + II glioma (adjusted OR = 0.58, 95%CI = 0.37 − 0.92, P = 0.019).