(49),using whole genome sequencing of fungal isolates from patients with cystic fibrosis and chronic pulmonary aspergillosis demonstrated than parasexual recombination is critical for A. fumigatus adaptation and might also be a driver for the development of azole resistance beyond the occurrence of point mutations in the CYP51 (Erg11) (Figure 1) (50). This evidence concerns the gene CYP51A1 and cystic fibrosis.