IFNG and neoplasm: Apart from genetic modification, to enrich Exos with more HSP70, external heat stimulation was applied to tumor cells, and the HSP70-enriched Exos (HS Exo) was shown to increase the expression of MHC-II and achieve higher productions of IgG2a and IFN-γ, resulting in strong Th1 immune responses and eliminating cancer cells (169).