Research found that Exos secreted from α-fetoprotein (AFP)-expressing DCs (DEXAFP) stimulated CD8+ T lymphocytes to express IFN-γ and secrete IL-2, which leaded to the reduced CD25+Foxp3+ Treg, IL-10 and TGF-β in the tumor microenvironment (158). This evidence concerns the gene TGFB1 and neoplasm.