PFKFB3 and malignant colon neoplasm: The significant differences were demonstrated for the baseline expression of PFKFB3, NR4A1 and IL1b, which was more than 2 times upregulated in colon cancer compared to healthy control (0,52 (0,43-1,04) vs. 0,23 (0,18-0,36), p= 0,0007; 2,10 (0,83-4,30) vs. 0,30 (0,20-2,75), p=0,02, and 1,60 (0,76-2,82) vs. 0,18 (0,07-0,46), p=0,00081, relatively) (Supplementary Figure S5).