In RC patients with lymphatic metastasis, statistically significant decrease in the percentage of classical CD14+CD16-CCR2+ monocytes was found compared to patients without lymphatic metastasis (21,26 (10,55-63,41) vs. 70,90 (18,71-88,96), p=0,013) (Figure 2C). Here, CCR2 is linked to Lymphatic Metastasis.