Other variants or heterozygosity in ABCB4 can lead to PL-associated cholelithiasis (gallstone disease) or intrahepatic cholestasis of pregnancy (ICP) in women, while ABCB4 variants also associate with elevated liver function tests, gallbladder and bile duct carcinoma and liver cirrhosis (Boyer, 2013; Andress et al., 2014; Stättermayer et al., 2020). The gene discussed is ABCB4; the disease is bile duct carcinoma.