GPT and type 2 diabetes mellitus: Furthermore, SimPops simulations using AMG-009 (100 mg BID for 2 weeks; ALT > 3x ULN in 1 out of 8 patients), solithromycin (IV-to-oral dosing: IV 400 mg on days 1–3, PO 800 mg QD on day 4, PO 400 mg QD on days 5–7; ALT > 3x ULN in 5.4%–9.1% of patients) and TAK875 (50 mg QD for 30 days; ALT > 3x ULN in 1.8%–3.2% of type 2 diabetes patients) reasonably recapitulated ALT > 3x ULN: 4.9%, 3.9% and 6.0% using the full SimPops, respectively.