Jian Zheng (Zheng et al., 2022)analyzed the B and T cell subsets comparing SLE patients in the low activity phase and healthy controls, and the T and B cell axes showed abnormalities, and the proportion of double negative B cells and CD8+ T cells was significantly reduced, the results indicated that the immune phenotype and the incidence of the disease were closely related. The gene discussed is CD8A; the disease is systemic lupus erythematosus.