Compared to the MM1 phenotype, significantly more patients with the MM2 (CD64 high) phenotype displayed involved to uninvolved FLC ratios > 100 at diagnosis after adjusting for sex, race, age, and treatment (p=0.009), suggesting that the MM2 phenotype may be reflective of myeloid dysregulation in MM patients with elevated FLC ratios (Figure 5C; Table 1). This evidence concerns the gene FCGR1A and Miyoshi myopathy.