Exosomes derived from the bone marrow stromal cells in MM patients alter myelopoiesis via activation of STAT1 and STAT3 pathways and increase of the levels of anti-apoptotic proteins Bcl-xL and Mcl-1 resulting in immature myeloid cells with immunosuppressive activity (72). The gene discussed is BCL2L1; the disease is Miyoshi myopathy.