Vascular Endothelial Growth Factor (VEGF) is over-expressed in a variety of metastatic tumours and bevacizumab (Avastin), an anti-VEGF antibody, was first approved for treatment in metastatic colorectal cancer in 2004 (98) and later for GBM treatment in 2009 (6). The gene discussed is VEGFA; the disease is metastatic neoplasm.