Vascular Endothelial Growth Factor (VEGF) is over-expressed in a variety of metastatic tumours and bevacizumab (Avastin), an anti-VEGF antibody, was first approved for treatment in metastatic colorectal cancer in 2004 (98) and later for GBM treatment in 2009 (6). This evidence concerns the gene VEGFA and metastatic colorectal cancer.