In addition, high throughput screens can incorporate the genetic diversity of GBM tumours by utilising GSCs from the main tumour-intrinsic transcriptional subtypes: Classical, Mesenchymal and Proneural as defined by aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 (70). The gene discussed is NF1; the disease is glioblastoma.