Thus, loss of StAR function affects the first step of steroidogenesis, inhibiting all steroid production in adrenal glands and gonads, leading to the most serious form of CAH, lipoid congenital adrenal hyperplasia (LCAH, OMIM 201710) (Kaur et al., 2016; Ullah et al., 2020). Here, STAR is linked to congenital adrenal hyperplasia.