METTL3 and esophageal cancer: In ESCC, Mettl3 promotes esophageal cancer initiation and progression (Chen X et al., 2021; Han Z et al., 2021b; Wang et al., 2021), followed by ALKBH5 (Nagaki et al., 2020; Xu et al., 2020; Xiao et al., 2021), FTO (Liu et al., 2020), YTHDC2 (Hu et al., 2020), HNRNPA2B1 (Guo et al., 2020) and HNRNPC (Xu et al., 2020).