Similarly, we found that the mRNA expression of 7 m6A regulators (YTHDF1, HNRNPC, FMR1, HNRNPA2B1, IGFBP3, ELAVL1, and IGF2BP1) was significantly upregulated in ESCC compared to normal tissues, while METTL3, RBM15B, YTHDC2, and IGFBP2 were significantly downregulated in ESCC. This evidence concerns the gene IGF2BP1 and esophageal squamous cell carcinoma.