The mRNA expression levels of 18 m6A regulators (METTL3, METTL16, WTAP, VIRMA, RBM15, CBLL1, YTHDF1, YTHDF3, HNRNPC, FMR1, LRPPRC, HNRNPA2B1, IGFBP3, RBMX1, ELAV1, IGF2BP1, FTO, and ALKBH5) were significantly increased in ESCC compared with normal tissues. The gene discussed is IGFBP3; the disease is esophageal squamous cell carcinoma.