The mRNA expression levels of 18 m6A regulators (METTL3, METTL16, WTAP, VIRMA, RBM15, CBLL1, YTHDF1, YTHDF3, HNRNPC, FMR1, LRPPRC, HNRNPA2B1, IGFBP3, RBMX1, ELAV1, IGF2BP1, FTO, and ALKBH5) were significantly increased in ESCC compared with normal tissues. Here, YTHDF1 is linked to esophageal squamous cell carcinoma.