At the same time, regarding the relationship between ESCC and YTHDF1, Lin et al. once reported that METTL3 induced epithelial-mesenchymal transition (EMT), which was an early metastasis event of YTHDF1-mediated m6A-increased Snail mRNA translation (Lin et al., 2019). The gene discussed is SNAI1; the disease is esophageal squamous cell carcinoma.