METTL3 and esophageal squamous cell carcinoma: Similarly, we found that the mRNA expression of 7 m6A regulators (YTHDF1, HNRNPC, FMR1, HNRNPA2B1, IGFBP3, ELAVL1, and IGF2BP1) was significantly upregulated in ESCC compared to normal tissues, while METTL3, RBM15B, YTHDC2, and IGFBP2 were significantly downregulated in ESCC.