Similarly, we found that the mRNA expression of 7 m6A regulators (YTHDF1, HNRNPC, FMR1, HNRNPA2B1, IGFBP3, ELAVL1, and IGF2BP1) was significantly upregulated in ESCC compared to normal tissues, while METTL3, RBM15B, YTHDC2, and IGFBP2 were significantly downregulated in ESCC. The gene discussed is RBM15B; the disease is esophageal squamous cell carcinoma.