Finally, we screened out IGFBP3, HNRNPA2B1, YTHDF1, YTHDC1, HNRNPC, YTHDF3, WTAP, FTO and RBM15 as m6A regulators significantly associated with ESCC according to the meanDecreaseGini score. The gene discussed is HNRNPA2B1; the disease is esophageal squamous cell carcinoma.