ALKBH5 and esophageal squamous cell carcinoma: Among them, Xu et al.'s bioinformatics analysis combined with ESCC independent cohort studies found that higher expression of HNRNPC in ESCC tissue was associated with poorer prognosis of patients, furthermore, HNRNPC and ALKBH5 have been shown to be prognostic indicators associated with ESCC survival outcomes (Xu et al., 2020).