In ESCC, Mettl3 promotes esophageal cancer initiation and progression (Chen X et al., 2021; Han Z et al., 2021b; Wang et al., 2021), followed by ALKBH5 (Nagaki et al., 2020; Xu et al., 2020; Xiao et al., 2021), FTO (Liu et al., 2020), YTHDC2 (Hu et al., 2020), HNRNPA2B1 (Guo et al., 2020) and HNRNPC (Xu et al., 2020). This evidence concerns the gene YTHDC2 and esophageal squamous cell carcinoma.