GRIN1 (encoding NMDAR subunit n-methyl-D-aspartate 1) gene has been shown to be closely associated with neurodevelopmental disorders (Platzer et al., 1993), and its polymorphism has also been demonstrated as a potential biomarker for reducing the risk of PD in previous studies (Wu et al., 2010). This evidence concerns the gene GRIN1 and neurodevelopmental disorder.