PKCα inhibits the expression of peroxisome proliferator-activated receptor C coactivator 1(PGC-1) by inducing miR-129–2 in neural tube defect (NTD) embryonic mouse models, and the overexpression of PGC-1 protects neurons from mitochondrial dysfunction under oxidative stress in PD (Mudò et al., 2012). Here, PRKCA is linked to neural tube defect.