Wang W. et al. (2019) were the first to reveal that immunotherapy-activated CD8+ T cells induce ferroptosis in ovarian tumor cells, showing that ferroptosis is intimately associated with antitumor immunity. Furthermore, immunotherapy-activated CD8+ T cells induce ferroptosis in human melanoma and fibrosarcoma cells (Lang et al., 2019). Another study reported the identification of a new gene feature about ferroptosis, prognosis prediction, and immune microenvironment of OS and suggested that FRGs in patients with OS were closely related to the immune microenvironment (Zheng et al., 2022). This evidence concerns the gene CD8A and fibrosarcoma.