Roles for TMED9 in the regulation of cancer cell growth (Mishra et al., 2019; Ju et al., 2021; Yang et al., 2021), APP processing (Hasegawa et al., 2010; Bai et al., 2015), and protein degradation (Dvela-Levitt et al., 2019) underscore the importance of this cargo receptor in health and disease. Here, APP is linked to cancer.