Several SNPs (rs12126142 for IL-6ra, rs4959106 for IL-6, rs6734238 for IL-1ra, and rs10774624 for IL-27) were related with other phenotypes at the genome-wide significance level, containing smoking, height, body mass, high cholesterol, different fibrinogen levels, white blood cells and other autoimmune diseases (Supplementary Table 8). This evidence concerns the gene IL6 and autoimmune disease.