With exception for smoking (rs10774624 for IL-27) (29), body mass (rs10774624 for IL-27 and rs4959106 for IL-6) (30) and high cholesterol (rs4959106 for IL-6) (31), it was unlikely that other traits had pleiotropic effects on the observed associations between genetic predisposition to IL levels and prostate cancer risk. This evidence concerns the gene IL6 and prostate carcinoma.