According to the findings of a national cross-sectional study conducted by Jia's team in 2016, the prevalence of high level of proteinuria in patients with DR reached 47.8% among the 3,301 patients with T2DM (average age 59.34 ± 12.28 years, average DM course of 8.48 years) and the frequency of DR increased as urine albumin levels increased (15). The gene discussed is ALB; the disease is type 2 diabetes mellitus.