ACE and hypertensive disorder: It is also hypothesized that hypertension and SARS-CoV-2 interact with the ACE/Angiotensin II/AT1R axis, which promotes vasoconstriction and RAAS upregulation, as well as the vasodilatory ACE2/Ang (1–7)/AT2R axis, to promote viral entry, replication, and organ damage [24, 25].