Studies in a model of diet-induced obesity showed that the expression of the SAMD4B and GATA6 was significantly increased during the differentiation of stromal vascular cells into mature adipocytes, which suggesting that paternal high fat diet is associated with upregulation of SAMD4B and GATA6 genes [79]. The gene discussed is SAMD4B; the disease is obesity due to melanocortin 4 receptor deficiency.