It is suggested that SAMD4A promotes the activity of CUGBP1-containing translation complexes, and SAMD4A can restore the mRNA translation of MORF-related gene on chromosome 15 (MRG15), a target protein of the CUGBP1-eIF2α complex in DM1 myoblasts [26]. The gene discussed is CELF1; the disease is myotonic dystrophy type 1.