The researchers performed the single nucleotide polymorphism (SNP) analysis of rs1957358 in SAMD4A of 500 patients with oral cancer in India, and found that wild-type thymine (T) mutation to cytosine (C) significantly reduced the risk of oral cancer, such as rs1957358 TT mutation to rs1957358 TC, whereas rs1957358 TT reflected the increased risk [78]. Here, SAMD4A is linked to lip and oral cavity carcinoma.