Non-frail participants taking metformin had a lower prevalence of osteoarthritis and peripheral vascular disease and higher levels of fasting plasma glucose, hemoglobin A1c, triglyceride, prealbumin, albumin, and hemoglobin than those not taking metformin (Tables 4 and 5), which was in accordance with the results in Table 6. The gene discussed is TTR; the disease is peripheral vascular disease.