Rezende et al. pointed out that proteinuria mainly reflects podocyte damage in LN, by comparing the podocyte biomarkers, they found that the expressions of synaptopodin (69.2%), WT1 (69.2%), GLEPP1 (53.9%) and nephrin (60.0%) were retained in the pure membranous LN group, while only synaptopodin (2.6%), WT1 (7.7%), GLEPP1 (2.9%) and nephrin (9.4%) were retained in the proliferative LN group. The gene discussed is SYNPO; the disease is lobular neoplasia.