In the present study, we found no change in the number of TAMs or MDSCs in tumor tissues following repeated activation of CRHPVN neurons in tumor-bearing mice, whereas mRNA levels of HIF1α, GR and Tsc22d3 derived from TAMs and M-MDSCs in tumor tissues were dramatically increased by repeated activation of CRHPVN neurons in these mice. The gene discussed is HIF1A; the disease is neoplasm.