Our findings were similar to some previous studies on cancer; for example, PSAT1 was reported to regulate β-catenin/cyclin D1 signalling in breast cancer cells [39], PSAT1 was proven to affect the GSK3β/Snail pathway in esophageal cancer cells [40], and PSAT1 could influence the PI3K/AKT pathway in cervical cancer cells [41]. This evidence concerns the gene AKT1 and esophageal cancer.