Ye et al. reported that lncRNA LET was downregulated in ccRCC tissues and cells, which mediated the tumor suppression by directly binding with miR-373-3p to reduce the levels of dickkopf-1 (DKK1) and tissue inhibitor of metalloproteinase-2 (TIMP2) [122]. This evidence concerns the gene TIMP2 and nonpapillary renal cell carcinoma.