It has been demonstrated that VHL is mutated in ccRCC, and its mutation leads to an activation of hypoxia-inducible factor (HIF), thereby inducing the expression alteration of angiogenic factors including vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) [8]. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.