LncRNA GAS5 was downregulated in sorafenib-resistant ccRCC cells, which could upregulate the expression of SOX5 by binding with miR-21 and weaken the sorafenib sensitivity [129]. SOX5 belongs to the SOX family, which contains more than 20 members and some are highly expressed in chemotherapy-resistant cells [189]. The gene discussed is SOX5; the disease is nonpapillary renal cell carcinoma.