Indeed, by upregulating miRNA-30e-5p, DAPA inhibits myocardiocyte autophagy and heart failure, and by reducing miRNA-199a-3p, DAPA causes a reduction in cardiac Peroxisome proliferator-receptor (PPAR) levels, ameliorating mitochondrial fatty acid oxidation and improving cardiac function in patients with heart failure. The gene discussed is PPARA; the disease is heart failure.