NFKB1 and myocardial ischemia: Furthermore, in the atherosclerosis plaque and myocardial ischemia–reperfusion injury model, SIRT1 inhibits NF-kB activity by deacetylating p65 and eliminating the interaction between p300 and NF-kB, reducing Nitric Oxides (NOS) 2 and pro-inflammatory genes [12].