Consistent with the fact that VEGF production through dependent and independent pathways of hypoxia-inducible factor 1 (HIF-1) is promoted by stimulating the PI3K/AKT pathway in tumor cells [39], the PI3K/AKT pathway also contributes to the production of other angiogenic factors, including angiopoietin and nitric oxide. This evidence concerns the gene VEGFA and neoplasm.